Bühler jet loop reactors use high-velocity liquid jets to drive circulation through a loop, entraining gas and producing fine bubble dispersion. This combination provides strong, uniform mixing and excellent gas–liquid contact, achieving high oxygen transfer rates even in compact systems. Loop and nozzle designs are tailored to your target OTR, mixing intensity, and energy efficiency.

Jet loop reactors are ideal for highly aerobic fermentations where throughput and yield are key. The design supports high cell density operation and intensified production strategies, while maintaining tight control of process variables. Robust instrumentation and automation enable sophisticated process strategies, including real-time optimization and advanced control algorithms.

Materials and surface finishes are selected for hygienic operation and robust cleanability, with options for elevated hygiene levels as required. Comprehensive CIP/SIP concepts are integrated into both loop and vessel design, ensuring effective cleaning and sterilization of all wetted components. Jet loop systems can be delivered as modular skids or integrated lines, with seamless connection to Bühler upstream/downstream systems, media prep, gas supply, and product recovery.