CFD
Services

CFD Simulation

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Services

CFD Simulation

We use computational fluid dynamics (CFD) to understand and optimize flow, mixing, gas–liquid transfer, and shear in your bioreactors before steel is built. This helps you choose and configure the right reactor concept and scale it with confidence.

By virtually testing different designs and conditions, we reduce scale-up risk, protect sensitive cells and products, and create a stronger technical basis for equipment specification and investment decisions.

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Your benefits

Lower scale-up risk

Fewer failed trials and surprises when moving from lab and pilot to industrial volumes.

Better-performing reactors

Higher productivity and robustness through optimized mixing, gas transfer, and shear.

Stronger basis for decisions

CFD evidence to support reactor selection, equipment specification, and investments.

Explore our deep CFD expertise

CFD Simulation for your bioreactors

We apply CFD to evaluate different reactor concepts and operating conditions before you commit to hardware. By analyzing flow, mixing, gas dispersion, and shear at scale, we can predict performance, identify risks, and support robust reactor design and scale-up.

Reactor concepts & operating conditions

How CFD adds value

We use CFD to compare different reactor types and configurations, such as stirred tanks, airlift reactors, bubble columns, and jet loops. Operating parameters like impeller type, agitation speed, gas rate, and fill level can be tested virtually, helping you select concepts that best match your organism and process requirements.


What you get

  • Evaluation of reactor types (STR, airlift, bubble column, jet loop)
  • Comparison of design options and operating windows
  • Recommendations for promising concepts to take into testing
Flow, mixing, gas dispersion & shear

How CFD adds value

Detailed CFD analysis reveals velocity fields, mixing times, dead zones, gas dispersion, bubble behavior, and kLa for oxygen-limited processes. We also identify shear hotspots that could damage sensitive cells or products, enabling you to adjust design and operation before building or modifying equipment.


What you get

  • Maps of flow patterns, mixing quality, and dead zones
  • Quantification of gas dispersion, bubble behavior, and kLa
  • Identification of shear hotspots and mitigation strategies
Support for design, scale-up & investments

How CFD adds value

CFD results feed directly into reactor design and scale-up from lab and pilot to industrial volumes. By linking hydrodynamics to process performance, we provide a strong technical basis for equipment specification, vendor discussions, and investment decisions – and help you avoid costly redesigns later.


What you get

  • Design guidance for new reactors and retrofits
  • Support for scaling operating conditions from lab/pilot to production
  • Evidence-based input for equipment specifications and CAPEX decisions
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Got Questions? Let's talk.


bioprocessing@buhlergroup.com